The association of the N-terminal pro-brain-type natriuretic peptide response to exercise with disease severity in therapy-naive pulmonary arterial hypertension: a cohort study

Autor: J. Kutsch, C. Faul, W. von Scheidt, M. Schwaiblmair, T. M. Berghaus
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Respiratory Research, Vol 19, Iss 1, Pp 1-6 (2018)
Druh dokumentu: article
ISSN: 1465-993X
DOI: 10.1186/s12931-017-0712-9
Popis: Abstract Background While the N-terminal pro-brain-type natriuretic peptide (NT-proBNP) at rest is known to be associated with prognosis in pulmonary arterial hypertension (PAH), it is unclear if the NT-proBNP response to exercise (ΔNT-proBNP) can contribute to a better assessment of disease severity. Methods We investigated the association of NT-proBNP values at rest and during peak exercise with hemodynamics and cardiopulmonary exercise testing parameters in 63 therapy-naive PAH patients. Results The median NT-proBNP increases from 1414 at rest to 1500 pg/ml at peak exercise. The ΔNT-proBNP is baseline-dependent in PAH. Both, NT-proBNP at rest and NT-proBNP at peak exercise, are significantly correlated with hemodynamics and functional capacity. However, neither NT-proBNP at peak exercise nor ΔNT-proBNP correlated better with surrogate markers of disease severity than NT-proBNP at rest. Conclusion The ΔNT-proBNP does not contribute to a better assessment of disease severity in PAH.
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