RAS-driven oncogenesis is supported by downstream antioxidant programs
Autor: | Jonathan K. M. Lim, Gabriel Leprivier, Poul H. Sorensen |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: | |
Zdroj: | Molecular & Cellular Oncology, Vol 7, Iss 1 (2020) |
Druh dokumentu: | article |
ISSN: | 2372-3556 23723556 |
DOI: | 10.1080/23723556.2019.1654814 |
Popis: | In our recent study, we demonstrated that oncogenic RAS (rat sarcoma)-mediated transformation and tumorigenesis are supported by transcriptional induction of a crucial antioxidant component, SLC7A11 (solute carrier family 7 member 11), otherwise known as XCT, a gene encoding the cystine/glutamate transporter. Our data highlight that this promotes the biosynthesis of glutathione, in turn allowing RAS transformed cells to mitigate tumorigenesis-linked oxidative stress. |
Databáze: | Directory of Open Access Journals |
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