RAS-driven oncogenesis is supported by downstream antioxidant programs

Autor:	Jonathan K. M. Lim, Gabriel Leprivier, Poul H. Sorensen
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Molecular & Cellular Oncology, Vol 7, Iss 1 (2020)
Druh dokumentu:	article
ISSN:	2372-3556 23723556
DOI:	10.1080/23723556.2019.1654814
Popis:	In our recent study, we demonstrated that oncogenic RAS (rat sarcoma)-mediated transformation and tumorigenesis are supported by transcriptional induction of a crucial antioxidant component, SLC7A11 (solute carrier family 7 member 11), otherwise known as XCT, a gene encoding the cystine/glutamate transporter. Our data highlight that this promotes the biosynthesis of glutathione, in turn allowing RAS transformed cells to mitigate tumorigenesis-linked oxidative stress.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/a60ab5753a35473a8cc74063d0e535c3 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF