Headache in Multiple Sclerosis: A Narrative Review
| Autor: | Bożena Adamczyk, Natalia Morawiec, Sylwia Boczek, Karol Dańda, Mikołaj Herba, Aleksandra Spyra, Agata Sowa, Jarosław Szczygieł, Monika Adamczyk-Sowa |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Medicina, Vol 60, Iss 4, p 572 (2024) |
| Druh dokumentu: | article |
| ISSN: | 60040572 1648-9144 1010-660X |
| DOI: | 10.3390/medicina60040572 |
| Popis: | Background: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disorder of the central nervous system characterized by autoimmune-mediated damage to oligodendrocytes and subsequent myelin destruction. Clinical implications: Clinically, the disease presents with many symptoms, often evolving over time. The insidious onset of MS often manifests with non-specific symptoms (prodromal phase), which may precede a clinical diagnosis by several years. Among them, headache is a prominent early indicator, affecting a significant number of MS patients (50–60%). Results: Headache manifests as migraine or tension-type headache with a clear female predilection (female-male ratio 2-3:1). Additionally, some disease-modifying therapies in MS can also induce headache. For instance, teriflunomide, interferons, ponesimod, alemtuzumab and cladribine are associated with an increased incidence of headache. Conclusions: The present review analyzed the literature data on the relationship between headache and MS to provide clinicians with valuable insights for optimized patient management and the therapeutic decision-making process. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|