Successful Treatment of Crizotinib-Induced Fulminant Liver Failure: A Case Report and Review of Literature

Autor:	Kyle Kreitman, Satheesh P. Nair, Jiten P. Kothadia
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Diseases of the digestive system. Gastroenterology RC799-869
Zdroj:	Case Reports in Hepatology, Vol 2020 (2020)
Druh dokumentu:	article
ISSN:	2090-6587 2090-6595
DOI:	10.1155/2020/8247960
Popis:	Crizotinib is a first-line tyrosine kinase inhibitor used for the treatment of metastatic lung cancer. Crizotinib-induced hepatotoxicity is a rare event. We report a case of a 46-year-old female with a history of metastatic lung cancer who presented with acute liver failure after being on crizotinib for two months. The medication was discontinued, and she was treated with N-acetylcysteine for seven days. Her liver function tests returned to normal limits after 26 days after admission. The precise mechanism and risk factors of crizotinib-induced hepatotoxicity remain unknown. Physicians should be aware of the potentially lethal side effect caused by crizotinib.
Databáze:	Directory of Open Access Journals
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