| Autor: |
Nora Rebeka Javorniczky, Olga Grishina, Inga Hund, Milena Pantic, Dietmar Pfeifer, Claudia Schmoor, Johanna Thomas, Justus Duyster, Heiko Becker, Michael Lübbert |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-5 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1868-7083 |
| DOI: |
10.1186/s13148-023-01596-5 |
| Popis: |
Abstract Elderly patients with AML ineligible for induction have a dismal prognosis; hence disease stabilization is a primary treatment goal. This case of a 75-year-old patient with secondary AML receiving the combination of decitabine and ATRA (within the DECIDER trial, NCT00867672) demonstrates an above-average survival. The therapy administered over 52 cycles led to complete molecular and hematological remission and resulted in 5.3 years overall survival. Clonal evolution of the leukemic clone could be demonstrated using DNA sequencing methods. According to the literature, this case constitutes the longest continued HMA exposure in an elderly AML patient ineligible for standard chemotherapy. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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