Antiulcer mechanisms of the hydroalcoholic extract from Aztec marigolds’ medicinal and edible flowers (Tagetes erecta L.)
| Autor: | MARIANE MEURER, FABIULA FELISBINO, FABIANA B. MÜLLER, LINCON B. SOMENSI, BENHUR J. CURY, DANIELE T. JERÔNIMO, LARISSA VENZON, TAUANI C.S. FRANÇA, MARIHÁ MARIOTT, ANA C. SANTOS, RUAN KAIO S. NUNES, THAISE BOEING, ALEXANDRE BELLA-CRUZ, PRISCILA DE SOUZA, WALTER A. ROMAN-JUNIOR, KARUPPUSAMY ARUNACHALAM, RUBERLEI G. OLIVEIRA, LUISA M. SILVA |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Anais da Academia Brasileira de Ciências, Vol 95, Iss suppl 1 (2023) |
| Druh dokumentu: | article |
| ISSN: | 1678-2690 0001-3765 |
| DOI: | 10.1590/0001-3765202320220427 |
| Popis: | Abstract The antiulcer mechanisms of the dry extract of T. erecta flowers (DETe) were studied here. The acute ulcers induced by acidified ethanol or indomethacin were reproduced in mice pretreated with DETe (3 - 300 mg/kg). The antiulcer activity of DETe was also verified in mice pretreated with NEM, L-NAME, indomethacin, or yohimbine. The antisecretory effect of DETe was verified in rats, and its anti-Helicobacter pylori activity was determined in vitro. DETe (300 mg/kg, p.o) reduced the ethanol- or indomethacin-induced ulcer by 49 and 93%, respectively. The pre-treatment with L-NAME, NEM or yohimbine abolished the gastroprotective effect of DETe. However, DETe did not change the volume, acidity, or peptic activity in rats and did not affect H. pylori. This study expands knowledge about the antiulcerogenic potential of DETe, evidencing the role of nitric oxide, non-protein sulfhydryl groups, α2 adrenergic receptors, and prostaglandins, but not antisecretory or anti-H. pylori properties. |
| Databáze: | Directory of Open Access Journals |
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