| Autor: |
Luane Ferreira Garcia, Carlos Eduardo Peixoto da Cunha, Emily Kussmaul Gonçalves Moreno, Douglas Vieira Thomaz, Germán Sanz Lobón, Rafael Luque, Vernon Somerset, Eric de Souza Gil |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Pharmaceuticals, Vol 11, Iss 4, p 99 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
1424-8247 |
| DOI: |
10.3390/ph11040099 |
| Popis: |
Methyldopa is a catecholamine widely used in the treatment of mild to moderate hypertension whose determination in pharmaceutical formulae is of upmost importance for dose precision. Henceforth, a low-cost carbon paste electrode (CPE) consisting of graphite powder obtained from a crushed pencil stick was herein modified with nanostructured TiO2 (TiO2@CPE) aiming for the detection of methyldopa in pharmaceutical samples. The TiO2-modified graphite powder was characterized by scanning electron microscopy and X-ray diffraction, which demonstrated the oxide nanostructured morphology. Results evidenced that sensitivity was nonetheless increased due to electro-catalytic effects promoted by metal modification, and linear response obtained by differential pulse voltammetry for the determination of methyldopa (pH = 5.0) was between 10–180 μmol/L (Limit of Detection = 1 μmol/L) with the TiO2@CPE sensor. Furthermore, the constructed sensor was successfully applied in the detection of methyldopa in pharmaceutical formulations and excipients promoted no interference, that indicates that the sensor herein developed is a cheap, reliable, and useful strategy to detect methyldopa in pharmaceutical samples, and may also be applicable in determinations of similar compounds. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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