Thromboelastography Parameters Suggestive of Hypercoagulability and its Correlation with Thrombotic Complications in Liver Transplantation- A Retrospective Study
| Autor: | satish logidasan, kanimozhi rathinasamy, gowrishankar anjeneyan |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Journal of Clinical and Diagnostic Research, Vol 15, Iss 19, Pp 15-19 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2249-782X 0973-709X |
| DOI: | 10.7860/JCDR/2021/51085.15802 |
| Popis: | Introduction: Conventional coagulation parameters like, Prothrombin Time (PT), International Normalised Ratio (INR) reflects only the synthesis or status of procoagulant factor levels. Whereas, Thromboelastograph (TEG) reflects ongoing coagulation process and helps in identifying hypocoagulable or hypercoagulable status. The hypercoagulable TEG parameters in the perioperative period can guide the physicians to prevent adverse thrombotic complications, instead of depending on the Conventional Coagulation Tests (CCTs), which has the potential to mislead and may delay appropriate clinical interventions. Aim: To establish, if correlation exists between TEG parameters suggestive of hypercoagulability and the occurrence of perioperative thrombotic complications and also to see if CCT correlates with hypercoagulable TEG parameters in liver transplantation. Materials and Methods: This was a retrospective analysis which was done in 32 patients of Diseased Donor Liver Transplantion (DDLT), from August 2018 to September 2019 at tertiary care centre in Chennai, Tamil Nadu, India. Data were analysed for correlation with hypercoagulable TEG parameters and perioperative thrombotic events. Thromboelastograph parameters were also compared with CCT like INR, platelet count. The Mann-Whitney U-test was considered significant if p-value |
| Databáze: | Directory of Open Access Journals |
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