Fractal dimension analysis of resting state functional networks in schizophrenia from EEG signals

Autor: Juan Ruiz de Miras, Antonio J. Ibáñez-Molina, María F. Soriano, Sergio Iglesias-Parro
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Frontiers in Human Neuroscience, Vol 17 (2023)
Druh dokumentu: article
ISSN: 1662-5161
DOI: 10.3389/fnhum.2023.1236832
Popis: Fractal dimension (FD) has been revealed as a very useful tool in analyzing the changes in brain dynamics present in many neurological disorders. The fractal dimension index (FDI) is a measure of the spatiotemporal complexity of brain activations extracted from EEG signals induced by transcranial magnetic stimulation. In this study, we assess whether the FDI methodology can be also useful for analyzing resting state EEG signals, by characterizing the brain dynamic changes in different functional networks affected by schizophrenia, a mental disorder associated with dysfunction in the information flow dynamics in the spontaneous brain networks. We analyzed 31 resting-state EEG records of 150 s belonging to 20 healthy subjects (HC group) and 11 schizophrenia patients (SCZ group). Brain activations at each time sample were established by a thresholding process applied on the 15,002 sources modeled from the EEG signal. FDI was then computed individually in each resting-state functional network, averaging all the FDI values obtained using a sliding window of 1 s in the epoch. Compared to the HC group, significant lower values of FDI were obtained in the SCZ group for the auditory network (p
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