Crystal structure of 5,11-dihydropyrido[2,3-b][1,4]benzodiazepin-6-one
| Autor: | Noura M. Riad, Darius P. Zlotos, Ulrike Holzgrabe |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Acta Crystallographica Section E: Crystallographic Communications, Vol 71, Iss 5, Pp o304-o305 (2015) |
| Druh dokumentu: | article |
| ISSN: | 2056-9890 20569890 |
| DOI: | 10.1107/S2056989015006817 |
| Popis: | The title compound, C12H9N3O, is an intermediate in the synthesis of the muscarinic M2 receptor antagonist AFDX-384. The seven-membered ring adopts a boat conformation and the dihedral angle between the planes of the aromatic rings is 41.51 (9)°. In the crystal, molecules are linked into [001] chains of alternating inversion dimers formed by pairs of N—H...O hydrogen bonds and pairs of N—H...N hydrogen bonds. In both cases, R22(8) loops are generated. |
| Databáze: | Directory of Open Access Journals |
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