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Objective Methods 120 elderly patients suffering from aneurysmal subarachnoid hemorrhage and receiving craniotomy from June 2019 to June 2021 were enrolled. Patients were randomly and equally divided into two groups: the traditional group(n=60, who received traditional nursing model) and the ERAS group (n=60, who received ERAS-based sputum drainage nursing model). The expectoration volume, blood oxygen saturation and proinflammatory cytokine level between traditional group and ERAS group were compared. Results At 5th day after intervention, the daily expectoration volume [(40. 51±9. 25) mL vs. (22. 52±4. 25) mL, P<0. 01] and blood oxygen saturation[(94. 52±4. 57)% vs. (84. 25±5. 11)%, P<0. 01]in the ERAS group were better than those in the traditional group. The percentage of effective expectoration in the ERAS group was higher than that in the traditional group (91. 67% vs, 76. 67%, P<0. 05). At 5th day after intervention, Patients receiving ERAS-based nursing model had a lower proinflammatory cytokine level (IL-1β, IL- and TNF-α)comparing with patients receiving traditional nursing model (P |