Morphine modulates hippocampal neurogenesis and contextual memory extinction via miR-34c/Notch1 pathway in male ICR mice

Autor: Hu JieWei, Cui FuHua, Zhang XiaoDong
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Open Life Sciences, Vol 15, Iss 1, Pp 51-59 (2020)
Druh dokumentu: article
ISSN: 2391-5412
DOI: 10.1515/biol-2020-0006
Popis: The opioid Morphine is known to affect neurogenesis in the hippocampus. Evidence has shown that several microRNAs modulate morphine-induced neurogenesis, and hence morphine-induced contextual memory. This complex network has yet to be elucidated. In this study, we screened for morphine addiction related microRNA and determined its effects on hippocampal neurogenesis and morphine-induced contextual memory using the conditioned place preference (CPP) model.
Databáze: Directory of Open Access Journals