Activation of the CA2-ventral CA1 pathway reverses social discrimination dysfunction in Shank3B knockout mice

Autor: Elise C. Cope, Samantha H. Wang, Renée C. Waters, Isha R. Gore, Betsy Vasquez, Blake J. Laham, Elizabeth Gould
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-023-37248-8
Popis: The SHANK3 gene is linked to autism spectrum disorder and Phelan McDermid syndrome, which have been associated with social memory deficits. Here, authors show activation of the hippocampal CA2-ventral CA1 circuit in adult Shank3B knockout mice restores social memory.
Databáze: Directory of Open Access Journals