| Autor: |
Xiaoyu Chen, Josephine M. Janssen, Jin Liu, Ignazio Maggio, Anke E. J. ‘t Jong, Harald M.M. Mikkers, Manuel A. F. V. Gonçalves |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-017-00687-1 |
| Popis: |
CRISPR-Cas9-based gene editing involves double-strand breaks at target sequences, which are often repaired by mutagenic non-homologous end-joining. Here the authors use Cas9 nickases to generate coordinated single-strand breaks in donor and target DNA for precise homology-directed gene editing. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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