Identification of CTNNB1 in the lined seahorse, Hippocampus erectus, and its function in innate immunity and cell proliferation

Autor: Lele Zhang, Fang Wang, Chunhui Lv, Lanliang Yu, Xiaojing Ci, Ning Zhang, Longwu Jia, Yuanyuan Xue, Xu Zhang, Xiaolei Su, Kai Wang
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of the World Aquaculture Society, Vol 55, Iss 3, Pp n/a-n/a (2024)
Druh dokumentu: article
ISSN: 1749-7345
0893-8849
DOI: 10.1111/jwas.13061
Popis: Abstract β‐Catenin (CTNNB) is a core downstream mediator in the Wnt/β‐catenin signaling pathway, which plays a role in immune regulation and cell differentiation. In the present study, two CTNNB genes were identified by genomic analysis of Hippocampus erectus and named He‐CTNNB1 and He‐CTNNB2. He‐CTNNB1 was more conserved than He‐CTNNB2. The full length of He‐CTNNB1 was 2369 bp, including an open reading frame of 2275 bp that encoded 737 amino acids containing 12 armadillo repeats. Phylogenetic analysis revealed that He‐CTNNB1 clusters had homologs in other bony fishes. Tissue distribution analysis showed the highest mRNA expression of He‐CTNNB1 in the ovary, liver, and kidney of the lined seahorse under normal physiological conditions. The transcription level of He‐CTNNB1 was significantly increased in the liver and kidney in response to LPS, poly I:C, and Edwardsiella tarda challenge (p
Databáze: Directory of Open Access Journals
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