Decreased level of irisin, a skeletal muscle cell-derived myokine, is associated with post-stroke depression in the ischemic stroke population

Autor: Wen-Jun Tu, Han-Cheng Qiu, Qiang Liu, Xuemei Li, Ji-Zong Zhao, Xianwei Zeng
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-10 (2018)
Druh dokumentu: article
ISSN: 1742-2094
DOI: 10.1186/s12974-018-1177-6
Popis: Abstract Background Depression is a frequent mood disorder in stroke patient. Our aim was to determine irisin levels in serum and investigate their associations with post-stroke depression (PSD) in a 6-month follow-up study in Chinese patients with first-ever acute ischemic stroke (AIS). Methods The subjects were first-ever AIS patients who were hospitalized at three stroke centers during the period from January 2015 to December 2016. Neurological and neuropsychological evaluations were conducted at the 6-month follow-up. Serum irisin concentrations were measured by enzyme-linked immunosorbent assay (ELISA). Results During the study period, 1205 patients were included in the analysis. There were 370 patients (30.7%) classified as depression. The depression distribution across the irisin quartiles ranged between 49.8% (first quartile) and 9.9% (fourth quartile). In the patients with depression, serum irisin levels were lower compared with those in patients without depression (P
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