| Autor: |
Rena Levin-Klein, Shira Fraenkel, Michal Lichtenstein, Louise S. Matheson, Osnat Bartok, Yuval Nevo, Sebastian Kadener, Anne E. Corcoran, Howard Cedar, Yehudit Bergman |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/ncomms15575 |
| Popis: |
B cell development involves sequential rearrangement of the immunoglobulin chains, but fine control over the selection process remains a mystery. Here the authors show that individual alleles in pre-B cells are clonally unique and result from stochastic activation of V gene segments to induce optimal generation of a diverse repertoire. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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