Early venous thromboembolism at the beginning of palliative chemotherapy is a poor prognostic factor in patients with metastatic pancreatic cancer: a retrospective study

Autor:	Jung Sun Kim, Eun Joo Kang, Dae Sik Kim, Yoon Ji Choi, Suk Young Lee, Hong Jun Kim, Hee Yeon Seo, Jun Suk Kim
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Pancreatic cancer Venous thromboembolism Prognosis Predictive value Chemotherapy Khorana score Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	BMC Cancer, Vol 18, Iss 1, Pp 1-10 (2018)
Druh dokumentu:	article
ISSN:	1471-2407
DOI:	10.1186/s12885-018-5154-3
Popis:	Abstract Background This study investigated the prognostic effects of venous thromboembolism (VTE)-related factors in patients with metastatic pancreatic cancer receiving palliative chemotherapy. Predictive factors for VTE were also investigated. Methods A total of 216 patients diagnosed with metastatic pancreatic cancer who received gemcitabine-based palliative chemotherapy at our institution were retrospectively evaluated. Results VTE occurred in 51 (23.6%) patients during treatment and did not affect survival. However, patients who were diagnosed with VTE at the beginning of chemotherapy showed poor prognosis compared with patients diagnosed with VTE during chemotherapy: all patients (hazard ratio [HR] 1.897, p = 0.008); patients diagnosed with VTE (HR = 3.768, p = 0.001). Low serum sodium (Na) (
Databáze:	Directory of Open Access Journals
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