| Autor: |
Simon Toupance, Mirna Chahine, Irini Tzanetakou, Carlos Labat, Sylvie Gautier, Cécilé Lakomy, Pascal Rossi, Toufic Moussallem, Pierre Yared, Didier Quilliot, Evangelos Menenakos, Roland Asmar, Athanase Benetos |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Artery Research, Vol 24 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
1876-4401 |
| DOI: |
10.1016/j.artres.2018.10.194 |
| Popis: |
Background: The relation between telomere dynamics and obesity remains unclear. Cross-sectional studies found associations between short leukocyte telomere length (LTL) and high body mass index (BMI) but longitudinal studies did not find any association between LTL attrition and BMI. In two parallel studies, we aimed to assess the relationship between obesity and telomere dynamics in different tissues. Methods: Study 1: Measurements of LTL and TL in skeletal muscle (MTL) were performed in 53 subjects with severe obesity (BMI > 35) and in 53 age- and sex-matched without obesity (21 < BMI < 30). MTL is a proxy of TL at birth and the LTL/MTL ratio represents life-long telomere attrition. Study 2: Measurements of TL in subcutaneous fat (SCF), a high proliferative adipose tissue, and visceral fat (VF), a low proliferative one in 50 severe obese bariatric patients. TL measurements were performed by Southern blot. Results: Study 1: In younger ( |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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