Janus kinase-1 and 3 in ankylosing spondylitis

Autor: Hsien-Tzung Liao, Tzu-Hao Li, Chun-Hsiung Chen, Hung-An Chen, Wei-Sheng Chen, Chien-Chih Lai, Chung-Tei Chou, Chang-Youh Tsai
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Journal of the Formosan Medical Association, Vol 118, Iss 1, Pp 134-141 (2019)
Druh dokumentu: article
ISSN: 0929-6646
DOI: 10.1016/j.jfma.2018.02.001
Popis: Background/purpose: To investigate the Janus kinase-1 and 3 (JAK-1 and 3) expression in peripheral blood mononuclear cells (PBMCs) in ankylosing spondylitis (AS). Methods: The levels of JAK-1 and JAK-3 mRNA in PBMCs, CD3+ T cells and CD14+ monocytes were measured by RT-PCR in 52 AS patients and 31 healthy controls (HCs). The demographic features, BASDAI, BASFI, HLA-B27, ESR, CRP and serum immunoglobulin A (IgA) level were recorded and correlated with the JAK-1 & JAK-3 transcripts in patients and HCs as appropriate. Results: JAK-1 and JAK-3 expression in PB CD3+ T cells plus CD14+ monocytes was significantly higher in AS patients than in HCs (p 4) and BASFI (>4) than ESR or CRP in AS patients. Conclusion: In AS, JAK-1 expression in PB cells rather than ESR or CRP might be regarded as a bio-marker for monitoring disease activity and functional index in AS. These findings have also suggested that JAK-1 and JAK-3 expression may play a role in the inflammatory processes in patients with AS. Keywords: Ankylosing spondylitis, Janus kinase (JAK), Acute-phase reactant
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