Single-cell transcriptomics of a dynamic cell behavior in murine airways

Autor: Sheldon JJ Kwok, Daniel T Montoro, Adam L Haber, Seok-Hyun Yun, Vladimir Vinarsky
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: eLife, Vol 12 (2023)
Druh dokumentu: article
ISSN: 2050-084X
DOI: 10.7554/eLife.76645
Popis: Despite advances in high-dimensional cellular analysis, the molecular profiling of dynamic behaviors of cells in their native environment remains a major challenge. We present a method that allows us to couple the physiological behaviors of cells in an intact murine tissue to deep molecular profiling of individual cells. This method enabled us to establish a novel molecular signature for a striking migratory cellular behavior following injury in murine airways.
Databáze: Directory of Open Access Journals