Shortening of leucocyte telomere length is independently correlated with high body mass index and subcutaneous obesity (predominantly truncal), in Asian Indian women with abnormal fasting glycemia
| Autor: | Surya Prakash Bhatt, Anoop Misra, Ravindra Mohan Pandey, Ashish Datt Upadhyay |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | BMJ Open Diabetes Research & Care, Vol 10, Iss 4 (2022) |
| Druh dokumentu: | article |
| ISSN: | 2021-0027 2052-4897 |
| DOI: | 10.1136/bmjdrc-2021-002706 |
| Popis: | Introduction Leucocyte telomere length (LTL) is linked to accelerate aging and premature mortality. In this research, we aimed to explore the relations between biochemical and anthropometry markers and LTL in Asian Indian women with abnormal fasting glycemia (impaired fasting glucose).Research design and methods In this study, 797 pre-diabetic women (obese, 492; non-obese, 305) were recruited. Demographic and clinical profiles, anthropometry, and fasting blood glucose were evaluated. LTL was quantified by a quantitative PCR. LTL was expressed as the relative telomere length or telomere repeat:single copy gene (T:S) ratio. The subjects were separated into quartiles according to the LTL.Results The average LTL was significantly decreased with increasing age. The average LTL was significantly shorter in obese women with abnormal fasting glycemia (p |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|