Sex Differences in Spontaneous Degranulation Activity of Intrahepatic Natural Killer Cells during Chronic Hepatitis B: Association with Estradiol Levels
| Autor: | Zuzana Macek Jilkova, Thomas Decaens, Alice Marlu, Hélène Marche, Evelyne Jouvin-Marche, Patrice N. Marche |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Mediators of Inflammation, Vol 2017 (2017) |
| Druh dokumentu: | article |
| ISSN: | 0962-9351 1466-1861 |
| DOI: | 10.1155/2017/3214917 |
| Popis: | Major sex differences are observed in the prevalence, intensity, and severity of hepatitis B virus (HBV) infection. Here, we investigated degranulation activity of circulating and intrahepatic natural killer (NK) cells from HBV and HCV chronically infected patients before any treatment (n=125). The frequency of CD107+ NK cells in the female liver was significantly higher compared to that in males during chronic HBV infection (p=0.002) and correlated with the plasma levels of estradiol (correlation coefficient r=0.634; p |
| Databáze: | Directory of Open Access Journals |
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