Impact of colonoscopy on health-related quality of life: findings from the RECEDE study

Autor: L. Andronis, N. Waugh, M. Zanganeh, A. Krishnamoorthy, N. Parsons, M. Hull, P. Wheatstone, R. P. Arasaradnam, On behalf of the RECEDE study group
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Health and Quality of Life Outcomes, Vol 22, Iss 1, Pp 1-10 (2024)
Druh dokumentu: article
ISSN: 1477-7525
DOI: 10.1186/s12955-024-02262-x
Popis: Abstract Background Colonoscopy is a valuable diagnostic tool but the procedure and the preparation for it cause anxiety and discomfort that impacts on patients’ health-related quality of life (HRQoL). The ‘disutility’ of undergoing an invasive colonoscopy needs to be considered and accounted for in comprehensive cost-utility analyses that compare different diagnostic strategies, yet there is little empirical evidence that can be used in such studies. To fill this gap, we collected and analysed data on the effect of a colonoscopy examination on patients’ HRQoL that can be used in economic evaluations. Methods Patients scheduled to undergo a colonoscopy at a large NHS hospital were asked to complete the EuroQol EQ-5D-5 L instrument: (i) before the procedure, at the time of consent (T1), (ii) while undergoing bowel preparation (T2) and (iii) within 24 h after the procedure (T3). Complete responses were translated into preference-based HRQoL (utility) values using a UK-specific value set and were analysed using descriptive and inferential statistical analyses. Results Two-hundred and seventy-one patients with gastrointestinal symptoms referred for a colonoscopy provided complete EQ-5D-5 L questionnaires at all three assessment points. At T1, the mean EQ-5D-5 L value was 0.76 (95%CI: 0.734–0.786). This value dropped to 0.727 at T2 (95%CI: 0.7–0.754, before increasing again to 0.794 (95%CI: 0.768–0.819) at T3. Both changes were statistically significant (p-value
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