| Autor: |
Pan Gao, Xiaoguang Pan, Shang Wang, Sijia Guo, Zhanying Dong, Zhefeng Wang, Xue Liang, Yan Chen, Fang Fang, Ling Yang, Jinrong Huang, Chenxi Zhang, Conghui Li, Yonglun Luo, Songlin Peng, Fengping Xu |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Heliyon, Vol 10, Iss 1, Pp e23675- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2405-8440 |
| DOI: |
10.1016/j.heliyon.2023.e23675 |
| Popis: |
Postmenopausal osteoporosis is the most common type of osteoporosis in women. To date, little is known about their transcriptome signatures, although biomarkers from peripheral blood mononuclear cells are attractive for postmenopausal osteoporosis diagnoses. Here, we performed bulk RNA sequencing of 206 samples (124 postmenopausal osteoporosis and 82 normal samples) and described the clinical phenotypic characteristics of postmenopausal women. We then highlighted the gene set enrichment analyses between the extreme T-score group and the heathy control group, revealing that some immune-inflammatory responses were enhanced in postmenopausal osteoporosis, with representative pathways including the mitogen-activated protein kinase (NES = 1.6, FDR |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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