I-131-Metaiodobenzylguanidine therapy with allogeneic cord blood stem cell transplantation for recurrent neuroblastoma

Autor: Sato Yuya, Kurosawa Hidemitsu, Fukushima Keitaro, Okuya Mayuko, Hagisawa Susumu, Sugita Kenichi, Arisaka Osamu, Inaki Anri, Wakabayashi Hiroshi, Nakamura Ayane, Fukuoka Makoto, Kayano Daiki, Kinuya Seigo
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Zdroj: Italian Journal of Pediatrics, Vol 38, Iss 1, p 53 (2012)
Druh dokumentu: article
ISSN: 1824-7288
1720-8424
DOI: 10.1186/1824-7288-38-53
Popis: Abstract Iodine-131-metaiodiobenzylguanidine (131I-MIBG) therapy combined with allogeneic cord blood stem cell transplantation (SCT) was used to treat a 4-year-old girl with recurrent neuroblastoma. The patient experienced relapse 2 years after receiving first-line therapies, which included chemotherapy, surgical resection, irradiation, and autologous peripheral SCT. Although 131I-MIBG treatment did not achieve complete remission, the size of the tumor was reduced after treatment. Based on our findings, we suggest that 131I-MIBG treatment with myeloablative allogeneic SCT should be considered as first-line therapy for high-risk neuroblastoma patients when possible.
Databáze: Directory of Open Access Journals
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