Modulatory effect of D-pinitol on bleomycin-induced pulmonary fibrosis in rats

Autor: Yu-Ling Duan, Zhi-Hua Wang, Yan-Xia Huo, Yang Zhang, Xiao-Ran Wu, Cui-Ke Gong, Lin-Lin Bai
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Asian Pacific Journal of Tropical Biomedicine, Vol 13, Iss 5, Pp 205-213 (2023)
Druh dokumentu: article
ISSN: 2221-1691
2588-9222
DOI: 10.4103/2221-1691.377407
Popis: Objective: To assess the effect of D-pinitol on pulmonary fibrosis induced by bleomycin. Methods: Sprague-Dawley rats received intratracheal bleomycin (6 IU/kg) to induce pulmonary fibrosis, followed by administration of either D-pinitol (5, 10, or 20 mg/kg) or vehicle or methylprednisolone (10 mg/kg) over 28 days after bleomycin administration. Lung function, biochemical parameters, serum biochemistry, mRNA expressions, and histological features were observed. Results: D-pinitol at 10 and 20 mg/kg significantly (P
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