Intracytoplasmic Expression of IL-6 and IL-17A in Circulating CD4+ T Cells Are Strongly Associated with and Predict Disease Activity in Rheumatoid Arthritis: A Case-Control Study in Ghana

Autor: Samuel Asamoah Sakyi, Tonnies Abeku Buckman, Daniel Antwi-Berko, Kwame Yeboah-Mensah, Dzifa Dey, Eddie-Williams Owiredu, Benjamin Amoani, Richard Mantey
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: International Journal of Rheumatology, Vol 2020 (2020)
Druh dokumentu: article
ISSN: 1687-9260
1687-9279
DOI: 10.1155/2020/2808413
Popis: Background. T cell cytokines play important roles in the development and progression of rheumatoid arthritis (RA). Loss of Th1/Th2 and Th17/Treg balance has been reported in several inflammatory autoimmune diseases. However, their role in RA within hitherto rare Ghanaian context has not been explored. Here, we evaluated the intracytoplasmic CD4+ T cell cytokine patterns in rheumatoid arthritis patients in Ghana and determined their relationship with disease activity. Methods. This case-control study included 48 newly diagnosed RA patients and 30 apparent healthy controls from two major hospitals in Ghana. Validated structured questionnaires were administered to obtain demographic data; blood samples were collected and processed for flow cytometric analysis. Results. IFN-γ, TNF-α, IL-4, IL-6, IL-10, IL-17A, IL-6/IL-4, and IL-17/IL-10 expressions were significantly higher in RA cases compared to the healthy controls. The expression of IL-6 (0.00 (0.00-0.98) vs. 0.82 (0.34-1.10) vs. 1.56 (1.39-1.68), p
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