Ca2+ homeostasis and male fertility: a target for a new male contraceptive system

Autor: Kyung-Ha Lee, Jae Yeon Hwang
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Animal Cells and Systems, Vol 28, Iss 1, Pp 171-183 (2024)
Druh dokumentu: article
ISSN: 19768354
2151-2485
1976-8354
DOI: 10.1080/19768354.2024.2345647
Popis: Ca2+ is a key secondary messenger that determines sperm motility patterns. Mammalian sperm undergo capacitation, a process to acquire fertilizing ability, in the female reproductive tract. Capacitated sperm change their flagellar waveform to develop hyperactivated motility, which is crucial for successful sperm navigation to the eggs and fertilization. The sperm-specific channel, CATSPER, and an ATPase transporter, PMCA4, serve as major paths for Ca2+ influx and efflux, respectively, in sperm. The ionic paths coordinate Ca2+ homeostasis in the sperm, and their loss-of-function impairs sperm motility, to cause male infertility. In this review, we summarize the physiological significance of these two Ca2+ gates and suggest their potential applications in novel male contraceptives.
Databáze: Directory of Open Access Journals
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