Rapid HIV disease progression following superinfection in an HLA-B*27:05/B*57:01-positive transmission recipient

Autor: Jacqui Brener, Astrid Gall, Jacob Hurst, Rebecca Batorsky, Nora Lavandier, Fabian Chen, Anne Edwards, Chrissy Bolton, Reena Dsouza, Todd Allen, Oliver G. Pybus, Paul Kellam, Philippa C. Matthews, Philip J. R. Goulder
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Retrovirology, Vol 15, Iss 1, Pp 1-13 (2018)
Druh dokumentu: article
ISSN: 1742-4690
DOI: 10.1186/s12977-018-0390-9
Popis: Abstract Background The factors determining differential HIV disease outcome among individuals expressing protective HLA alleles such as HLA-B*27:05 and HLA-B*57:01 remain unknown. We here analyse two HIV-infected subjects expressing both HLA-B*27:05 and HLA-B*57:01. One subject maintained low-to-undetectable viral loads for more than a decade of follow up. The other progressed to AIDS in
Databáze: Directory of Open Access Journals
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