Clinical relevance of paramagnetic rim lesion heterogeneity in multiple sclerosis

Autor:	Anna Stölting, Colin Vanden Bulcke, Serena Borrelli, Céline Bugli, Renaud Du Pasquier, Vincent vanPesch, Pietro Maggi
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Zdroj:	Annals of Clinical and Translational Neurology, Vol 11, Iss 12, Pp 3137-3151 (2024)
Druh dokumentu:	article
ISSN:	2328-9503
DOI:	10.1002/acn3.52220
Popis:	Abstract Objective Previous studies reveal heterogeneity in terms of paramagnetic rim lesions (PRL) associated tissue damage. We investigated the physiopathology and clinical implications of this heterogeneity. Methods In 103 MS patients (72 relapsing and 31 progressive), brain lesions were manually segmented on 3T 3D‐FLAIR and rim visibility was assessed with a visual confidence level score (VCLS) on 3D‐EPI phase. Using T1 relaxation time maps, lesions were categorized in long‐T1 and short‐T1. Lesion age was calculated from time of first gadolinium enhancement (N = 84 lesions). Results on clinical scores were validated in an extended cohort of 167 patients using normalized T1w‐MPRAGE lesion values. Results Rim visibility (VCLS analysis) was associated with increasing lesional T1 (P/PFDR
Databáze:	Directory of Open Access Journals
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