| Autor: |
Hongxia Fu, Yan Jiang, Darren Yang, Friedrich Scheiflinger, Wesley P. Wong, Timothy A. Springer |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-017-00230-2 |
| Popis: |
Von Willebrand factor (VWF) is a blood protein involved in clotting and is proposed to be activated by flow, but the mechanism is unknown. Here the authors show that VWF is first converted from a compact to linear form by flow, and is subsequently activated to bind GPIbα in a tension-dependent manner. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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