Derepression may masquerade as activation in ligand-gated ion channels

Autor: Christian J. G. Tessier, Johnathon R. Emlaw, Raymond M. Sturgeon, Corrie J. B. daCosta
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Nature Communications, Vol 14, Iss 1, Pp 1-8 (2023)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-023-36770-z
Popis: Ligand-gated ion channels are activated/opened by agonists. Tessier et al. show that agonists can inhibit the inhibition of intrinsic basal activity, and thus that activation may instead be the manifestation of a derepression mechanism.
Databáze: Directory of Open Access Journals