Constipation-Predominant Irritable Bowel Syndrome Associated to Hyperprolactinemia

Autor: C. Seretis, F. Seretis, N. Liakos, A. Pappas, D. Keramidaris, S. Gourgiotis, N. Salemis, E. Lagoudianakis
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Zdroj: Case Reports in Gastroenterology, Vol 5, Iss 3, Pp 523-527 (2011)
Druh dokumentu: article
ISSN: 1662-0631
DOI: 10.1159/000331806
Popis: Irritable bowel syndrome (IBS) is considered to be a physical disorder that mainly affects the bowel and is clinically characterized by lower abdominal pain or discomfort, diarrhea, constipation (or alternating diarrhea/constipation), gas, bloating, and nausea. According to recent studies, it appears that there is an association with increased prolactin levels in patients suffering from IBS. We report a rare case of regression of IBS symptoms (constipation type) in a 16-year-old female adolescent after receiving cabergoline for treating hyperprolactinemia due to pituitary macroadenoma. Our hypothesis is that increased prolactin levels, for instance due to a pituitary adenoma, may suppress prolactin-releasing peptide release and lead to a reverse feedback interaction, consequently resulting in oversecretion of cholecystokinin, inducing the development of IBS.
Databáze: Directory of Open Access Journals