| Autor: |
Byoung-Seob Ko, Jin Ah Ryuk, Joo Tae Hwang, Ting Zhang, Xuangao Wu, Hye Jin Kim, Qiu Jing Yi, Sunmin Park |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Journal of Functional Foods, Vol 58, Iss , Pp 151-160 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2019.04.061 |
| Popis: |
Longitudinal bone growth mainly occurs during adolescence and can be enhanced by growth hormones. We hypothesized that water extracts from roots of Allium fistulosum L. (Welsh onion, WO; 15 or 45 mg/kg bw/day) and Portulaca oleracea L. (PO; 15 or 45 mg/kg bw/day) can stimulate longitudinal bone growth in weanling male rats for 4 weeks. Femur and tibia lengths were higher in the WO-H and PO-H groups than in the control. The proliferative and hypertrophic zones of the growth plate were greater in the legs of WO-H and PO-H rats than in the control; a similar increase was observed in the positive-control (growth hormone, 20 μg/kg bw/day). WO-H and PO-H treatments were found to potentiate insulin-like growth factor-1 (IGF-1) signaling (pIRS-2 → pAkt) in MG-63 osteoblasts compared to control. WO-H and PO increased cell proliferation possibly by activating transforming growth factor (TGF)-β signaling via elevated BMP-2 and Smad4 expression in MG-63 cells. In conclusion, WO and PO are potential to promote the proliferation of the leg growth plate similar to growth hormone. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect