Prognostic value of CYFRA 21 − 1 and Ki67 in advanced NSCLC patients with wild-type EGFR

Autor:	Tao Li, Qi Xie, Yang-Yang Fang, Yi Sun, Xiao Ming Wang, Zhu Luo, Gui-Ling Yan, Jian-Bo He, Xiao-Qun Zheng
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	CYFRA 21 − 1 Ki67 NSCLC Wild-type EGFR Prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	BMC Cancer, Vol 23, Iss 1, Pp 1-10 (2023)
Druh dokumentu:	article
ISSN:	1471-2407
DOI:	10.1186/s12885-023-10767-9
Popis:	Abstract Background The prognostic value of cytokeratin 19 fragment (CYFRA 21 − 1) and Ki67 in advanced non-small cell lung cancer (NSCLC) patients with wild-type epidermal growth factor receptor (EGFR) remains to be explored. Methods In this study, 983 primary NSCLC patients from January 2016 to December 2019 were retrospectively reviewed. Finally, 117 advanced NSCLC patients with wild-type EGFR and 37 patients with EGFR mutation were included and prognostic value of CYFRA 21 − 1 and Ki67 were also identified. Results The patients age, smoking history and the Eastern Corporative Oncology Group (ECOG) performance scores were significantly different between CYFRA21-1 positive and negative groups (p
Databáze:	Directory of Open Access Journals
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