Gdn3+@CNTs-PEG versus Gadovist®: In Vitro Assay
| Autor: | Ghazal Mehri-Kakavand, Hadi Hasanzadeh, Rouzbeh Jahanbakhsh, Maryam Abdollahi4,, Reza Nasr, Ahmad Bitarafan-Rajabi, Majid Jadidi, Amir Darbandi-Azar, Alireza Emadi |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Oman Medical Journal, Vol 34, Iss 2, Pp 147-155 (2019) |
| Druh dokumentu: | article |
| ISSN: | 1999-768X 2070-5204 |
| DOI: | 10.5001/omj.2019.27 |
| Popis: | Objectives: Carbon nanotubes (CNTs) are allotropes of carbon with a length-to-diameter ratio greater than 106 with the potential uses as medical diagnostic or therapeutic agents. In vitro studies have revealed that gadolinium (Gd) nanoparticle-catalyzed single-walled carbon nanotubes (SWCNTs) possess superparamagnetic properties, which enable them to be used as contrast agents in magnetic resonance imaging (MRI). Our study synthesized Gd-CNT for use as MRI contrast agents. Methods: To reduce the toxicity and solubility of CNTs, it was functionalized, and after loading with Gd was coated with polyethylene glycols (PEG). We then synthesized different concentrations of Gdn3+@CNTs-PEG and Gadovist® to be evaluated as MRI contrast agents. Results: The analysis showed that the Gd concentration in Gadovist® was 12.18% higher than synthesized Gdn3+@CNTs-PEG, but the mean signal intensity of the Gdn3+@CNTs-PEG was approximately 3.3% times higher than Gadovist®. Conclusions: Our findings indicate that synthesized Gdn3+@CNTs-PEG has the potential to be used as an MRI contrast agent in vitro, but in vivo assessment is necessary to determine the bio-distribution, kinetic, and signal enhancement characteristics. |
| Databáze: | Directory of Open Access Journals |
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