Effects of the Hydro-Alcoholic Extract of Chamomile (Matricaria recutita) on Acute and Chronic Pain in the Presence and Absence of Estrogen Receptors in Adult Male and Female Mice
| Autor: | M Kesmati, A Davoodi Korani, M Torabi |
|---|---|
| Jazyk: | English<br />Persian |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 17, Iss 7, Pp 66-73 (2015) |
| Druh dokumentu: | article |
| ISSN: | 1561-4107 2251-7170 |
| Popis: | BACKGROUND AND OBJECTIVE: Chamomile has several analgesic properties, while the mechanism of these effects in interaction with male sex hormones compared tofemales are not well known. This study aimedto evaluate the analgesic effects of hydro-alcoholic extract of chamomile in male mice, and two phases of femalesexual cycle (diestrus and proestrus) in the presence or absence of estrogen receptors. METHODS: In this experimental study, adult mice of both genders(weight: 27±3 g) were divided into four groups of control, chamomile recipients (30 or 50 mg/kg), tamoxifen recipients (0.5 or 1 mg/kg), and recipients of combined tamoxifen (1 mg/kg) and chamomile (30 or 50 mg/kg). Drugs were administeredintraperitoneally in one milligram per a kilogram of the body weight, and formalin test was used to induce acute and chronic pain. In addition, cumulative length of foot licking was calculatedin seconds as theindicator of pain perception. FINDINGS: In male mice,chamomile extract (30mg/kg) reduced acute pain (53±2, p |
| Databáze: | Directory of Open Access Journals |
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