Vaccine development for pathogenic fungi: current status and future directions

Autor: Jéssica L. Chechi, Felipe A. C. da Costa, Julia M. Figueiredo, Cássia M. de Souza, Alessandro F. Valdez, Daniel Zamith-Miranda, Aline C. Camara, Carlos P. Taborda, Joshua D. Nosanchuk
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Expert Review of Vaccines, Vol 22, Iss 1, Pp 1136-1153 (2023)
Druh dokumentu: article
ISSN: 14760584
1744-8395
1476-0584
DOI: 10.1080/14760584.2023.2279570
Popis: ABSTRACTIntroduction Fungal infections are caused by a broad range of pathogenic fungi that are found worldwide with different geographic distributions, incidences, and mortality rates. Considering that there are relatively few approved medications available for combating fungal diseases and no vaccine formulation commercially available, multiple groups are searching for new antifungal drugs, examining drugs for repurposing and developing antifungal vaccines, in order to control deaths, sequels, and the spread of these complex infections.Areas covered This review provides a summary of advances in fungal vaccine studies and the different approaches under development, such as subunit vaccines, whole organism vaccines, and DNA vaccines, as well as studies that optimize the use of adjuvants. We conducted a literature search of the PubMed with terms: fungal vaccines and genus of fungal pathogens (Cryptococcus spp. Candida spp. Coccidioides spp. Aspergillus spp. Sporothrix spp. Histoplasma spp. Paracoccidioides spp. Pneumocystis spp. and the Mucorales order), a total of 177 articles were collected from database.Expert opinion Problems regarding the immune response development in an immunocompromised organism, the similarity between fungal and mammalian cells, and the lack of attention by health organizations to fungal infections are closely related to the fact that, at present, there are no fungal vaccines available for clinical use.
Databáze: Directory of Open Access Journals
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