| Autor: |
Sepideh Yamini, Zohre Eftekhari, Mohammad Reza Mokhber Dezfouli, Babak Beikzadeh, Parvane Mehrbod |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Medical Laboratory Journal, Vol 13, Iss 6, Pp 17-22 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2538-4449 |
| Popis: |
ABSTRACT Background and Objectives: Exogenous lung surfactant (ELS) obtained from extraction of bronchoalveolar lavage fluid, is prescribed in some respiratory disorders, which could affect production of lung-related cytokines. Interleukin-8 (IL-8) is a major cytokine that could affect severity of lung diseases. In this study, we investigate the possible impact of ELS on IL-8 expression, hematological parameters and IgG and IgM levels in rabbits. Methods: ELS solution obtained from fresh calf’s lung bronchoalveolar lavage was infused into the lungs of five rabbits via tracheal tube. Blood samples were collected before and after ELS treatment for 30 days. Results: Serum IL-8 levels decreased over time following ELS administration. IL-8 expression also decreased after exposure to ELS, but leukocytes count increased significantly 24, 48 and 72 hours after ELS therapy compared to baseline values (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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