Prognostic features and comprehensive genomic analysis of NF1 mutations in EGFR mutant lung cancer patients

Autor:	Hong‐xia Tian, Zhi‐hong Chen, Guang‐Ling Jie, Zhen Wang, Hong‐hong Yan, Si‐pei Wu, Shui‐lian Zhang, Dan‐xia Lu, Xu‐chao Zhang, Yi‐long Wu
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	epidermal growth factor receptor lung cancer molecular typing next‐generation sequencing NF1 gene overall survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Cancer Medicine, Vol 12, Iss 1, Pp 396-406 (2023)
Druh dokumentu:	article
ISSN:	2045-7634
DOI:	10.1002/cam4.4925
Popis:	Abstract Objective NF1 is a tumor suppressor gene that encodes the neurofibromin protein and negatively regulates Ras signaling. This study was aimed to investigate the molecular, clinical characteristics, and prognostic features of NF1 gene in EGFR mutant lung cancer patients. Method The next‐generation sequencing (NGS) was used to analyze the data from lung cancer patients in the Guangdong Lung Cancer Institute (GLCI) from June 2016 to December 2020. Results Somatic NF1 mutations were present in 4.2% (135/3220) of Chinese lung cancer patients. NF1 mutations where clearly enriched in older (p
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/e5f7395017c04009a1b841fdf49f70cf Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.