Autor: |
Hong‐xia Tian, Zhi‐hong Chen, Guang‐Ling Jie, Zhen Wang, Hong‐hong Yan, Si‐pei Wu, Shui‐lian Zhang, Dan‐xia Lu, Xu‐chao Zhang, Yi‐long Wu |
Jazyk: |
angličtina |
Rok vydání: |
2023 |
Předmět: |
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Zdroj: |
Cancer Medicine, Vol 12, Iss 1, Pp 396-406 (2023) |
Druh dokumentu: |
article |
ISSN: |
2045-7634 |
DOI: |
10.1002/cam4.4925 |
Popis: |
Abstract Objective NF1 is a tumor suppressor gene that encodes the neurofibromin protein and negatively regulates Ras signaling. This study was aimed to investigate the molecular, clinical characteristics, and prognostic features of NF1 gene in EGFR mutant lung cancer patients. Method The next‐generation sequencing (NGS) was used to analyze the data from lung cancer patients in the Guangdong Lung Cancer Institute (GLCI) from June 2016 to December 2020. Results Somatic NF1 mutations were present in 4.2% (135/3220) of Chinese lung cancer patients. NF1 mutations where clearly enriched in older (p |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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