Overlap of spike and ripple propagation onset predicts surgical outcome in epilepsy

Autor: Saeed Jahromi, Margherita A.G. Matarrese, Lorenzo Fabbri, Eleonora Tamilia, M. Scott Perry, Joseph R. Madsen, Jeffrey Bolton, Scellig S.D. Stone, Phillip L. Pearl, Christos Papadelis
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Annals of Clinical and Translational Neurology, Vol 11, Iss 10, Pp 2530-2547 (2024)
Druh dokumentu: article
ISSN: 2328-9503
DOI: 10.1002/acn3.52156
Popis: Abstract Objective Interictal biomarkers are critical for identifying the epileptogenic focus. However, spikes and ripples lack specificity while fast ripples lack sensitivity. These biomarkers propagate from more epileptogenic onset to areas of spread. The pathophysiological mechanism of these propagations is elusive. Here, we examine zones where spikes and high frequency oscillations co‐occur (SHFO), the spatiotemporal propagations of spikes, ripples, and fast ripples, and evaluate the spike–ripple onset overlap (SRO) as an epilepsy biomarker. Methods We retrospectively analyzed intracranial EEG data from 41 patients with drug‐resistant epilepsy. We mapped propagations of spikes, ripples, and fast ripples, and identified their onset and spread zones, as well as SHFO and SRO. We then estimated the SRO prognostic value in predicting surgical outcome and compared it to onset and spread zones of spike, ripple, and fast ripple propagations, and SHFO. Results We detected spikes and ripples in all patients and fast ripples in 12 patients (29%). We observed spike and ripple propagations in 40 (98%) patients. Spike and ripple onsets overlapped in 35 (85%) patients. In good outcome patients, SRO showed higher specificity and precision (p
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