A simplified alternative diagnostic algorithm for SARS-CoV-2 suspected symptomatic patients and confirmed close contacts (asymptomatic): A consensus of Latin American experts

Autor: Fabian F. Fay, Carlos Arturo Alvarez-Moreno, Pablo E. Bonvehi, Carolina Cucho Espinoza, Marco Luis Herrera Hidalgo, Marcel Marcano-Lozada, Carlos M. Perez, Alvaro Pulchinelli Jr, Klever Vinicio Sáenz- Flor, Antonio Condino-Neto
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: International Journal of Infectious Diseases, Vol 117, Iss , Pp 130-136 (2022)
Druh dokumentu: article
ISSN: 1201-9712
DOI: 10.1016/j.ijid.2021.05.011
Popis: Introduction: Latin America accounts for one-quarter of global COVID-19 cases and one-third of deaths. Inequalities in the region lead to barriers to the best use of diagnostic tests during the pandemic. There is a need for simplified guidelines that consider the region’s limited health resources, international guidelines, medical literature, and local expertise. Methods: Using a modified Delphi method, 9 experts from Latin American countries developed a simplified algorithm for COVID-19 diagnosis on the basis of their answers to 24 questions related to diagnostic settings, and discussion of the literature and their experiences. Results: The algorithm considers 3 timeframes (≤7 days, 8–13 days, and ≥14 days) and presents diagnostic options for each. SARS-CoV-2 real- time reverse transcription-polymerase chain reaction is the test of choice from day 1 to 14 after symptom onset or close contact, although antigen testing may be used in specific circumstances, from day 5 to 7. Antibody assays may be used for confirmation, usually after day 14; however, if clinical suspicion is very high, but other tests are negative, these assays may be used as an adjunct to decision-making from day 8 to 13. Conclusion: The proposed algorithm aims to support COVID-19 diagnosis decision-making in Latin America.
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