Tumor-infiltrating CD8+ T cells combined with tumor-associated CD68+ macrophages predict postoperative prognosis and adjuvant chemotherapy benefit in resected gastric cancer

Autor:	Jun Lu, Yu Xu, Yuan Wu, Xiao-yan Huang, Jian-wei Xie, Jia-bin Wang, Jian-xian Lin, Ping Li, Chao-hui Zheng, Ai-min Huang, Chang-ming Huang
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Adjuvant chemotherapy benefit Gastric cancer Prognosis Tumor-infiltrating neutrophils Tumor-associated macrophages Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	BMC Cancer, Vol 19, Iss 1, Pp 1-10 (2019)
Druh dokumentu:	article
ISSN:	1471-2407
DOI:	10.1186/s12885-019-6089-z
Popis:	Abstract Background Tumor-infiltrating immune cells are present in various malignant tumors, but their clinical significance in gastric cancer (GC) remains unclear. This study aimed to investigate the prognostic significance of tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs). Methods Using a prospective database containing 401 cases of GC, we evaluated TIL (cluster of differentiation 8 (CD8) expression) and TAM (cluster of differentiation 68 (CD68) expression) statuses via immunohistochemical staining. Results Compared with CD8+ TIL-negative cases (n = 196, 48.6%), CD8+ TIL-positive cases (n = 205, 51.1%) showed significantly better recurrence-free survival (RFS) [log-rank p
Databáze:	Directory of Open Access Journals
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