Challenges and strategies associated with CAR-T cell therapy in blood malignancies

Autor:	Zhaoyun Liu, Wenhui Lei, Hao Wang, Xiaohan Liu, Rong Fu
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	CAR-T cell therapy Hematologic malignancies Resistance and relapse mechanisms Diseases of the blood and blood-forming organs RC633-647.5 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-22 (2024)
Druh dokumentu:	article
ISSN:	2162-3619
DOI:	10.1186/s40164-024-00490-x
Popis:	Abstract Cellular immunotherapy, particularly CAR-T cells, has shown potential in the improvement of outcomes in patients with refractory and recurrent malignancies of the blood. However, achieving sustainable long-term complete remission for blood cancer remains a challenge, with resistance and relapse being expected outcomes for many patients. Although many studies have attempted to clarify the mechanisms of CAR-T cell therapy failure, the mechanism remains unclear. In this article, we discuss and describe the current state of knowledge regarding these factors, which include elements that influence the CAR-T cell, cancer cells as a whole, and the microenvironment surrounding the tumor. In addition, we propose prospective approaches to overcome these obstacles in an effort to decrease recurrence rates and extend patient survival subsequent to CAR-T cell therapy.
Databáze:	Directory of Open Access Journals
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