Ameliorative Activity of Ethanolic Extract of Artocarpus heterophyllus Stem Bark on Alloxan-induced Diabetic Rats

Autor: Basiru Olaitan Ajiboye, Oluwafemi Adeleke Ojo, Oluwatosin Adeyonu, Oluwatosin Imiere, Babatunji Emmanuel Oyinloye, Oluwafemi Ogunmodede
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Advanced Pharmaceutical Bulletin, Vol 8, Iss 1, Pp 141-147 (2018)
Druh dokumentu: article
ISSN: 2228-5881
2251-7308
DOI: 10.15171/apb.2018.017
Popis: Purpose: Diabetes mellitus is one of the major endocrine disorders, characterized by impaired insulin action and deficiency. Traditionally, Artocarpus heterophyllus stem bark has been reputably used in the management of diabetes mellitus and its complications. The present study evaluates the ameliorative activity of ethanol extract of Artocarpus heterophyllus stem bark in alloxan-induced diabetic rats. Methods: Diabetes mellitus was induced by single intraperitoneal injection of 150 mg/kg body weight of alloxan and the animals were orally administered with 50, 100 and 150 mg/kg body weight ethanol extract of Artocarpus heterophyllus stem bark once daily for 21 days. Results: At the end of the intervention, diabetic control rats showed significant (p0.05) different with non-diabetic rats. Conclusion: The results suggest that ethanol extract of Artocarpus heterophyllus stem bark may be useful in ameliorating complications associated with diabetes mellitus patients.
Databáze: Directory of Open Access Journals
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