Autor: |
Dong Won Baek, Joon Ho Moon, Jae Hoon Lee, Ka-Won Kang, Ho Sup Lee, Hyeon-Seok Eom, Enuyoung Lee, Ji Hyun Lee, Jeong-Ok Lee, Seong Kyu Park, Seok Jin Kim, Keon Hee Yoo, Sung-Soo Yoon, Youngil Koh, Hyoung Jin Kang, Jong-Ho Won, Chuhl Joo Lyu, Seung Min Hahn, Jung-Hee Lee, Joon Seong Park, Jae-Cheol Jo, Yeung-Chul Mun, Deok-Hwan Yang, Ga-Young Song, Sung-Nam Lim, Sang Kyun Sohn, The Korean Society of Blood and Marrow Transplantation |
Jazyk: |
angličtina |
Rok vydání: |
2023 |
Předmět: |
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Zdroj: |
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-8 (2023) |
Druh dokumentu: |
article |
ISSN: |
2044-5385 |
DOI: |
10.1038/s41408-023-00868-w |
Popis: |
Abstract This study aimed to identify the benefits of autologous-stem cell transplantation (auto-SCT) and allogeneic-SCT (allo-SCT) in patients with aggressive T-cell lymphomas to aid in the selection of transplantation type in clinical practice. This study retrospectively analyzed data from 598 patients who underwent transplantation for T-cell lymphomas from 2010 to 2020. In total, 317 patients underwent up-front SCT as consolidation therapy. The 3-year progression-free survival (PFS) and overall survival (OS) were 68.7% and 76.1%, respectively. Patients who underwent auto-SCT had significantly better OS (p = 0.026) than those who underwent allo-SCT; however, no statistical difference in PFS was found. Transplantation was used as a salvage therapy in 188 patients who had relapsed/refractory disease. Overall, 96 (51.1%) patients underwent auto-SCT and 92 (48.9%) patients underwent allo-SCT. Auto-SCT improved long-term survival in patients with complete remission (CR). Allo-SCT demonstrated better 3-year PFS in patients with partial remission and relapsed/refractory disease status. However, >50% of patients died within 1 year of allo-SCT. As a consolidative therapy, up-front auto-SCT demonstrated a survival benefit. Auto-SCT was also effective in patients who achieved CR after salvage therapy. If the disease persists or cannot be controlled, allo-SCT may be considered with reduced intensity conditioning. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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