Effect of perindopril or leucine on physical performance in older people with sarcopenia: the LACE randomized controlled trial

Autor: The LACE study group, Marcus Achison, Simon Adamson, Asangaedem Akpan, Terry Aspray, Alison Avenell, Margaret M. Band, Tufail Bashir, Louise A. Burton, Vera Cvoro, Peter T. Donnan, Gordon W. Duncan, Jacob George, Adam L. Gordon, Celia L. Gregson, Adrian Hapca, Emily Henderson, Cheryl Hume, Thomas A. Jackson, Paul Kemp, Simon Kerr, Alixe Kilgour, Veronica Lyell, Tahir Masud, Andrew McKenzie, Emma McKenzie, Harnish Patel, Kristina Pilvinyte, Helen C. Roberts, Christos Rossios, Avan A. Sayer, Karen T. Smith, Roy L. Soiza, Claire J. Steves, Allan D. Struthers, Deepa Sumukadas, Divya Tiwari, Julie Whitney, Miles D. Witham
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 2, Pp 858-871 (2022)
Druh dokumentu: article
ISSN: 2190-6009
2190-5991
DOI: 10.1002/jcsm.12934
Popis: Abstract Background This trial aimed to determine the efficacy of leucine and/or perindopril in improving physical function in older people with sarcopenia. Methods Placebo‐controlled, parallel group, double‐blind, randomized two‐by‐two factorial trial. We recruited adults aged ≥ 70 years with sarcopenia, defined as low gait speed (
Databáze: Directory of Open Access Journals
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