| Autor: |
Núria eMallorquí-Bagué, Sarah N Garfinkel, Miriam eEngels, Jessica A Eccles, Guillem ePailhez, Antonio eBulbena, Hugo D Critchley |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
Frontiers in Psychology, Vol 5 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
1664-1078 |
| DOI: |
10.3389/fpsyg.2014.01162 |
| Popis: |
Objective: Anxiety is associated with increased physiological reactivity and also increased ‘interoceptive’ sensitivity to such changes in internal bodily arousal. Joint hypermobility, an expression of a common variation in the connective tissue protein collagen, is increasingly recognized as a risk factor to anxiety and related disorders. This study explored the link between anxiety, interoceptive sensitivity and hypermobility in a sub-clinical population using neuroimaging and psychophysiological evaluation. Methods: Thirty-six healthy volunteers undertook interoceptive sensitivity tests, a clinical examination for hypermobility and completed validated questionnaire measures of state, anxiety and body awareness tendency. Nineteen participants also performed an emotional processing paradigm during functional neuroimaging. Results: We confirmed a significant relationship between state anxiety score and joint hypermobility. Interoceptive sensitivity mediated the relationship between state anxiety and hypermobility. Hypermobile, compared to non-hypermobile, participants displayed heightened neural reactivity to sad and angry scenes within brain regions implicated in anxious feeling states, notably insular cortex. Conclusions: Our findings highlight the dependence of anxiety state on bodily context, and increase our understanding of the mechanisms through which vulnerability to anxiety disorders arises in people bearing a common variant of collagen. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
