| Autor: |
Mojtaba Hedayat Yaghoobi, Ehsan Heidari, Arman Shafiee, Niloofar Seighali, Mohammad Reza Maghsoodi, Mahmood Bakhtiyari |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
The Egyptian Heart Journal, Vol 76, Iss 1, Pp 1-9 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2090-911X |
| DOI: |
10.1186/s43044-024-00495-1 |
| Popis: |
Abstract Background Beyond its ability to decrease cholesterol, statin medication has been proved to have a variety of pleiotropic effects, such as anti-inflammatory and immunomodulatory effects. Statins are an appealing therapeutic option for individuals with infective endocarditis because of these effects, as the condition is linked to a strong inflammatory response. Methods A comprehensive search was done in Medline/PubMed, Cochrane database (CENTRAL), and Google Scholar to identify relevant studies reporting outcomes of interest (rate of mortality, intensive care unit admission, and embolic events) comparing those who are on statin therapy to nonusers were included. We performed a random effect meta-analysis to pool each study's individual results. Results Three articles were included in the study. The pooled results regarding our primary endpoint showed there was a significant reduction in mortality among statin users in all time points (1-year mortality: OR 0.69, 95% CI 0.61–0.79, I2: 0%; Chi2 = 0.01; p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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